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Treatment of human and mouse small intestine organoid models with SCFAs increases the number of GLP-1-producing cells twofold 284 , and SCFA infusion activates colonic EECs to increase GLP-1 release in mice 281

Faghfouri AH, Zarezadeh M, Tavakoli-Rouzbehani OM, Radkhah N, Faghfuri E, Kord-Varkaneh H, Ostadrahimi A (2020) The effects of N-acetylcysteine on inflammatory and oxidative stress biomarkers: A systematic review and meta-analysis of controlled clinical trials

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The free radicals produced during fuel burning in the mitochondria can be compared to some of the waste products produced by a cars combustion engine, some of which are removed by the oil filter, Sekhar said

Biochem Pharmacol 199:115005

The transition from a self-limiting seizure to a self-sustaining one is established by maladaptive receptor trafficking, whereby GABA A receptors are progressively endocytosed while glutamatergic receptors (NMDA and AMPA) are transported to the synaptic membrane, causing excitotoxicity and alteration in glutamate-dependent downstream signaling