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doi:10.1016/j.biocon.2003.07.002

In adipose tissue, metformin inhibits lipolysis while enhancing re-esterification of fatty acids

SCFAs as Major Metabolites of Intestinal Bacteria In recent years, studies investigating the interactions between gut microbiota and its host has focused on recognizing an essential factor that influences homeostasis

The hyperactive hypothalamicpituitarygonadal axis in PCOS patients results in excessive ovarian androgen production in theca cells via upregulation of CYP17A1 enzyme activity ( de novo lipid synthesis, leading to excess lipid accumulation and lipotoxicity ( 5 Inflammation and oxidative stress It has been widely accepted that chronic low-grade inflammation is involved in the pathogenesis of PCOS, mainly owing to the excessive fat accumulation observed, particularly in the visceral adipose tissues ( 6 Pathogenic signaling pathways 6.1 The PI3K/Akt signaling pathway The phosphoinositide-3 kinase/protein kinase B (PI3K/Akt) signaling pathway plays an essential role in cell survival and glucose homeostasis

Fernblock helps protect skin from sun exposure and environmental stress

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