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For heart failure or chronic kidney disease, the American Diabetes Association generally recommends SGLT2 inhibitors as first-line agents, with GLP-1 receptor agonists considered for their benefits on atherosclerotic cardiovascular disease, glycemic control, and weight management, or when SGLT2 inhibitors are not appropriate

Pregnant individuals are often advised to avoid medications not proven to be safe, especially in the first trimester when fetal development is most sensitive to external factors

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On average, they lost almost 15% of their body weight over 68 weeks