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Secretory transporters: e.g., organic anion transporters OAT1 and OAT3 (SLC22A6 and SLC22A8), ATP-binding cassette transporter G2 (ABCG2), sodium-dependent phosphate transporter 1 and 4 (NPT1/SLC17A1 and NPT4/SLC17A3), and multidrug resistance protein 4 (MRP4/ABCC4)

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Detection of nitric oxide (NO) production The serum NO concentrations in different groups were measured with the NO assay kit (Beyotime, Haimen, China) on the basis of Griess reaction following specific instructions

"There's a theory the free radical theory of aging that's been around for a long time that says when we oxidize our food to produce energy there's a number of free radicals that are produced that are side products of that action and many of these are quite toxic," said Beelman

This causes increased neuroinflammation in human brain vascular pericytes (Table 1), which further leads to neurovascular unit disruption and immune cell transmigration across the BBB (Niu et al., 2019

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