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Treatment starts with the minimum effective dosage, progressively tailored by your provider based on your response

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According to NICE guidance (NG28), Rybelsus may be used in combination with: Metformin (the first-line treatment for type 2 diabetes) Sulfonylureas (such as gliclazide) Sodium-glucose co-transporter-2 (SGLT2) inhibitors (such as dapagliflozin or empagliflozin) Insulin therapy when additional glycaemic control is required It's worth noting that combining GLP-1 receptor agonists like Rybelsus with DPP-4 inhibitors (such as sitagliptin) is not recommended in UK practice, as both drug classes work on similar pathways