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Intranasal administration is particularly studied for its ability to bypass the blood-brain barrier via retrograde axonal transport

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In addition, the lower mRNA expression levels of Bax and P53 and the higher expression levels of Bcl2 and Bcl-xL were detected in the peroxynitrite + ebselen group compared with the peroxynitrite-only group, while the lack of GPX1 in SGNs from gpx1 / mice led to an opposite pattern (Figure 8D)

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10.1038/clpt.2011.79