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Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion

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Free-energy calculations The interaction free energies ( G ) of P i and ND1L-p97 (wild type in states A and B as well as the mutant R359K) were calculated using the MMPBSA single-trajectory method as implemented in the MMPBSA.py 33 script, which is part of the AMBER18 package 53

A comparison of the enzyme-GSH structure reported here with previously described structures reveals rearrangements in a well-defined network of water molecules in the active site