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MASH resolved in patients treated with tirzepatide at one of three doses Launched in 2019, the SYNERGY-NASH trial evaluated tirzepatide in 196 overweight adults, ages 18-80, with biopsy-proven MASH and stage 2 or 3 liver fibrosis, reflecting moderate to significant fibrosis that hasnt progressed to cirrhosis

I argued last year that the GLP1a drug semaglutide was disease-modifying in patients with established heart disease and obesity because the SELECT trial showed reductions in hard clinical endpoints

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Normoglycaemia, previously considered unachievable, is becoming a potential reality in T2D

This date accounts for the stability of the tirzepatide and the risk of bacterial growth once the vial has been punctured