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Exogenous HGH delivers the hormone directly, bypassing the pituitary entirely

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Caloric restriction (CR), a reduction in caloric intake without malnutrition or starvation, is the most robust, non-pharmacological and reproducible intervention for extending lifespan in model organisms 3

there is a lack of sufficient reliable information on its effect on immunocompetent cells, and the potential health risks involved have not been adequately assessed

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Odawara M, Yoshiki M, Sano M, Hamada I, Lukashevich V, Kothny W