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The lack of human safety data creates uncertainty, but uncertainty is not the same as known danger

"Investor excitement for Roche's obesity franchise may now take a pause, in our view, given both acquired [drugs] showed higher-than-anticipated [gastroinsteinal] side effects," Jefferies analysts said in a note on Wednesday, noting that the trials aggressively increased patients' dosages of the drug

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Amazon's 24/7 on-demand telehealth service is exclusively for renewal of existing GLP-1 prescriptions where the patient has taken their medication within the past two weeks and is not requesting a dose change