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The microbiota is critical for maintaining intestinal homeostasis through activation of innate immune toll like receptors8 and could also play a causal role in the impaired mucosal integrity and repair seen in UC patients

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it stratifies the risk-benefit ratio of intensified intervention

5.2.3 Bottlenecks and opportunities in clinical translation While ferroptosis-targeted strategies show promise in OA models, the translation to clinical settings remains hindered by key limitations in safety, efficacy, and delivery

Naunyn-Schmiedeb Arch Pharmacol