Ro-3306 pafenac InChiKey: GJPXGFGIFQWUOC-ACFHMISVSA-N

InChiKey: GJPXGFGIFQWUOC-ACFHMISVSA-N

Chemical Name: Benzophenone

PubMed PMID: 25663935

841290-80-0 (Tamatinib free base)

QAW039 was also a potent inhibitor of PGD2-induced cytokine release in human Th2 cells

Ro-3306 pafenac InChiKey: GJPXGFGIFQWUOC-ACFHMISVSA-NRO 3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO 3306 induced G2 M phase cell cycle arrest and apoptosis in a dose and time dependent manner. RO 3306 downregulated expression of the antiapoptotic proteins Bcl 2 and survivin and blocked p53 mediated induction of p21 and MDM2. RO 3306 actively enhances downstream p53 signaling to promote apoptosis. Product information CAS Number: 872573 93 8