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Metformin boosts antitumor immunity and improves prognosis in upfront resected pancreatic cancer: an observational study

It is recommended that 20-30% of calories should be derived from fats

doi: 10.1016/j.clnu.2020.08.025 16

Jordan VC, et al

Key findings (Vafaei et al., 2025): 30-50 mg/kg mirtazapine: dose-dependent seizure suppression Mediated by CB1/CB2 activation (proven by antagonist blockade) GABA-independent mechanism (distinct from benzodiazepines) Appetite/weight gain provides in-vivo functional validation of CB1 engagement The broader implication: Clinicians and researchers have been using ECS pharmacologyunknowinglyfor decades