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In the lung, GSTT1 helps clear reactive epoxides and aldehydes from tobacco smoke and polluted air, which can otherwise damage airway cells and contribute to chronic obstructive pulmonary disease and lung cancer risk in the context of heavy exposure

PTEN phosphatase inhibits the activity of PI3K and thus impedes signaling through the insulin/IGF-1 pathway (Fig

facilitating over-stimulated or sustained inflammatory responses with interferon and cytokine release, influencing ROS production, iron storage, platelet coagulability, cytokine production stimulation, regulation of fission and fusion, mitochondrial biogenesis, and interference of apoptosis and mitophagy (312319)

In addition to the symptoms of iron deficiency, vitamin-deficiency anemia is associated with weight loss, diarrhea, muscle weakness, and mental confusion or forgetfulness (Mayo Clinic 2011h)

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