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It showed also anti-inflammatory properties by downregulating the expression of pro-inflammatory mediators, such as iNOS, COX-2, and TNF-, along with inhibition of the NF-B signaling pathway [75]

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The results showed that proteins related to mitochondrial fission (FIS1 and DRP1) increased with CR, but the three fusion proteins examined (MFN1, MFN2, and OPA1) did not exhibit changes (Khraiwesh et al., 2013)