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The MHRAs guidance confirms that switching between GLP-1 medicines should always be done with a healthcare professional, because the medications vary in strength, mechanism, and how theyre used

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Semaglutide starts working immediately, with some people reporting reduced appetite within days

Bottom line: Most individual Zepbound diarrhea episodes resolve within 13 days of an injection, and roughly 75% of users see loose stools fully clear within about 4 weeks as the body adapts to the medication

Who Is at Higher Risk for Mood Changes on GLP-1 Therapy Certain genetic profiles may increase vulnerability to mood fluctuations during tirzepatide treatment

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