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Next, a metabolic-syndrome study reported higher energy expenditure, increased fatty-acid oxidation, reduced fat-mass accumulation, and improved insulin sensitivity in mouse models

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It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number