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Therapeutically, small-molecule antioxidants and nutraceuticals laid the groundwork, but their limited organelle specificity and bioavailability have driven the development of mechanism-based approaches

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Originally designed to manage type 2 diabetes, these drugs led by blockbusters like Ozempic, Wegovy, and Zepbound are now driving one of the most profound shifts in public health, clinical practice, and the business of medicine

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2E, F), explained by negligible insulin secretion and severely impaired glucose disposal (Fig

Often referred to as the "master antioxidant," it plays a pivotal role in detoxification, immune function, and the maintenance of cellular health