tirzepatide in mash hits two receptors. Semaglutide hits one. The liver feels the difference. Both drugs work MASH. The question is whether the second receptor — GIP — adds meaningful hepatic benefit beyond Liver Disease Biotechs' Stocks Crash

Name: tirzepatide in mash hits two receptors. Semaglutide hits one. The liver feels the difference. Both drugs work MASH. The question is whether the second receptor — GIP — adds meaningful hepatic benefit beyond Liver Disease Biotechs' Stocks Crash
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Liver Disease Biotechs' Stocks Crash on Eli Lilly's Mounjaro Data Barron's EBM BLS: Tirzepatide Leads to Resolution of Metabolic Dysfunction Associated Steatohepatitis (MASH) Without Worsening of Fibrosis Journal of General Internal Medicine Springer Nature Link Eli Lilly's Tirzepatide Shows Promise in Treating Fatty Liver Disease Xtalks The percentage of participants who met the criteria for resolution of MASH without worsening of fibrosis was 10% in the placebo group compared to 62% in the 15 mg tirzepatide group, The percentage of Eli Lilly touts tirzepatide's midstage MASH win Newly released phase IIb 48 week liver biopsy data on #tirzepatide in #MASH. 73.9% resolution of MASH with no worsening of fibrosis on tirzepatide 15 mg. Secondary endpoint fibrosis by >1 stage

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Eligibility is determined by your physician

Oral incretin therapies do exist for semaglutide (Rybelsus), but tirzepatide is only FDA-approved as a subcutaneous injection

Initially developed for type 2 diabetes, these agents are now widely used to achieve significant weight loss in individuals with obesity or overweight with comorbidities