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It has been demonstrated that the number of GIP-producing cells, GIP content, and Pdx1 expression in GIP-producing cells increase in aged mice, while acquired Pdx1 knockdown using an intestine-specific gene transfer (iGT) technique decreases GIP gene expression and GIP content in GIP-producing cells and ameliorates GIP secretion after oral glucose loading

Lancet 394(10193):131138

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While Merrill sees potential for the future of GLP-1 drugs to be helpful outside treating type 2 diabetes and obesity, he also understands the need for more studies

(13) A key mechanism through which GLP-1 receptor agonists may influence bone metabolism is the osteoprotegerin (OPG)/RANKL/RANK pathway, which regulates osteoclast differentiation and bone resorption

No analysis was conducted in the subgroup of patients with HF at baseline (approximately 14%) to determine whether treatment with liraglutide was associated with any change of severity of HF and/or cardiovascular mortality