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It will require clinical trials by independent entities to delineate the true effectiveness and side effect profile of this and all new medications. Following the results of earlier trials, Novo Nordisk submitted a New Drug Application to the Food and Drug Administration (FDA) in December 2025 for the use of CagriSema to assist and maintain weight loss alongside diet and exercise adjustments

A 2025 global meta-analysis involving over 150,000 person-years of follow-up demonstrates that IBD patients have a pooled prevalence of depression symptoms of 22.8%25.2%, and anxiety symptoms of 32.1%33.8% (Table 3)

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Moreover, astaxanthin administration in a type-2 diabetic db/db (leptin receptor mutated) mice improved the intraperitoneal glucose tolerance test and protected pancreatic -cells against glucose toxicity by reducing blood glucose concentration and hyperglycemia-induced oxidative stress [65]